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CLIO conducts rigorous and relevant research: rigor entails adopting received research methodological approaches; relevance entails addressing research problems faced by managers and policymakers in practice and verifying hypotheses that connect variables within the control of practitioners to outcomes they care about.

Rigorous and relevance research entails transcending the traditional distinction between base and applied knowledge and focusing on the generation of knowledge as guided by its contexts of application.

CLIO intends to forge close collaboration with industrial partners in Italy and internationally by introducing new arrangements of industry-academia relationships such as Professorship-in-Residence (from academia to industry) and Professorship-of-Practice (from industry to academia).